ABSTRACT
Objective To investigate the correlation of serum urate and gout with calcific aortic stenosis.Methods Patients aged over 60 years admitted into our hospital from July 2009 to January 2019 were retrospectively analyzed.A total of 230 patients were diagnosed as calcific aortic stenosis according to clinical history and transthoracic echocardiography(TTE),and enrolled in the aortic stenosis group.During the same period,460 age-matched patients without aortic stenosis confirmed by TTE were randomly recruited in the 1 ∶ 2 case-control study.The correlations of calcific aortic stenosis with serum urate and gout were analyzed.According to the differential pressure across the valve leaflets assessed by TTE,patients with calcific aortic stenosis were divided into 3 subgroups:the mild stenosis subgroup(n=42),the moderate stenosis subgroup(n=79)and the severe stenosis subgroup(n =109).Relationships of serum urate and gout with different degrees of calcific aortic stenosis were analyzed.Risk factors for the degree of calcific aortic stenosis were analyzed by Logistic regression analysis.Results Serum urate level was higher in aortic stenosis group than in control group [(401.8±139.7) μmol/L vs.(320.7± 106.2) μmol/L,P＜0.05].And the proportion of patients with gout was higher in aortic stenosis group than in control group[11.3％ (26 cases) vs.5.0％ (23 cases),P＜ 0.05].Multivariate Logistic regression analysis indicated that serum urate (OR =3.47,95 ％CI:2.24～ 5.38,P ＜ 0.01) was an independent risk factor for calcific aortic stenosis,while gout (OR=1.41,95％CI:0.74～2.71,P =0.30)was not.There was no correlation of serum urate and gout with the severity of calcific aortic stenosis among the three subgroups(P＞0.05).Conclusions Serum urate level is significantly increased in patients with calcified aortic stenosis.Serum urate is an independent risk factor for calcified aortic stenosis,but has no relationship with stenosis degree.The correlation between gout and calcified aortic stenosis still needs to be further explored.